《植物生理学报》 2021, 57(5): 1023-1030

GUN1调控质体/叶绿体蛋白稳态的分子机制

孙雪萍¹，王兴军²，马长乐¹，李膨呈^1,2,*

¹山东师范大学生命科学学院, 济南250014；²山东省农业科学院生物技术研究中心, 山东省作物遗传育种与生态生理重点实验室, 济南250100

通信作者：李膨呈；E-mail: lpcsaas@outlook.com

摘　要：

细胞内蛋白稳态(proteostasis)的维持对机体正常生长发育至关重要。在植物细胞中, 质体/叶绿体作为半自主细胞器, 具有由核基因组和自身基因组编码的蛋白构成的蛋白质组。因此, 质体中蛋白稳态的维持不仅需要质体自身调控, 还需要其与细胞核之间通过逆行信号进行协调。 GUN1 (GENOMES UNCOUPLED 1)被认为是介导质体逆行信号的中央枢纽。最新研究结果进一步揭示GUN1在多维度参与调控质体蛋白稳态。本文重点综述GUN1调控质体蛋白稳态分子机制的研究进展。

关键词： 质体蛋白稳态; GUN1; 质体逆行信号; 叶绿体

收稿：2020-07-27   修定：2021-02-24

资助：国家自然科学基金(31500257)、山东省泰山学者项目 (ts20190964)和山东省农业科学院农业科技创新工程项目 (CXGC2018E13)。

Mechanisms for the regulation of chloroplast/plastid proteostasis by GUN1

SUN Xueping¹, WANG Xingjun², MA Changle¹, LI Pengcheng^1,2,*

¹College of Life Sciences, Shandong Normal University, Jinan 250014, China 2; ²Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Crop Genetic Improvement, Ecology and Physiology, Jinan 250100, China

Corresponding author: LI Pengcheng; E-mail: lpcsaas@outlook.com

Abstract:

The maintenance of protein homeostasis (proteostasis) is essential for organism’s normal growth and development. In plant cells, the chloroplast/plastid, as a semi-autonomous organelle, possesses a proteome that consists of proteins encoded by both the nuclear and its own genomes. Thus, the maintenance of plastid proteostasis is not only depended on the plastid’s self-regulation mechanism, but also needs its fne coordination with the nucleus through the retrograde communication. GUN1 (GENOME UNCOUPLED 1) is known as a central hub mediating the chloroplast-to-nucleus retrograde signaling. However, several recent studies have stated that GUN1 is also required for the self-regulation of plastid proteostasis through multiple pathways. Here, we summarizes advances in the molecular mechanism by which GUN1 maintains the plastid proteostasis.

Key words: plastid proteostasis; GUN1; plastid retrograde signaling; chloroplast